Production by controlled biosynthesis of a novel ionophore antibiotic, cezomycin (demethylamino A23187).
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چکیده
منابع مشابه
A23187: a divalent cation ionophore.
A23187 is a carboxylic acid antibiotic which simultaneously uncouples oxidative phosphorylation and inhibits ATPase of rat liver mitochondria incubated in a magnesium-free medium. The antibiotic acts as a freely mobile carrier to transport calcium and magnesium, but not potassium, from an aqueous medium buffered at pH 7.4 into a bulk organic phase. A23187 causes a progressive release of endogen...
متن کاملThe Journal of Antibiotics Biosynthesis of Antibiotic A23187 Incorporation of Precursors into A23187 Note
Streptomyces chartreusis NRRL 3881 produces the divalent cation ionophore antibiotic A231871). This antibiotic is primarily active against Grampositive bacteria and fungi and has been used extensively to investigate the role of divalent cations in regulating cellular physiological processes2,3,4). The chemical structure of A231875.6) indicates that it is a member of a new class of ionophorous a...
متن کاملParthenogenetic Activation of Porcine Oocytes by Calcium Ionophore A23187
This study was designated to clarify the influence of activation of porcine matured oocytes by calcium ionophore on in vitro development of the parthenotes. The follicular oocytes were matured, activated and cultured in North Carolina State University-23 (NCSU-23) medium supplemented with 10% porcine follicular fluid (pFF). The in vitro-matured oocytes were exposed to calcium ionophore at conce...
متن کاملThe structure of the calcium complex of A23187, a divalent cation ionophore antibiotic.
The crystal and molecular structures of the calcium complex of A23187 has been determined by X-ray diffraction studies.
متن کاملCalcium-dependent shortening of fibroblasts induced by the ionophore, A23187.
Attached, spread, chick heart fibroblasts were induced to shorten by treatment with the ionophore, A23187. The shortening resulted from the retraction of the leading lamellae and other major cell processes. The response was dependent on external calcium with a threshold close to, and a maximal effect at, physiological concentrations. The shortening was also induced in Colcemid-treated cells and...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1982
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.35.1409